MolLab

The scientific core of the MolLab headed by Prof. Daniele Di Marino and Prof. Anna La Teana is represented by the combination of different disciplines such as computational biophysics, structural biology, drug design, and molecular and cellular biology making the environment extremely multidisciplinary.

The main research lines in the lab span from the study of the regulation of the mRNA translation process to drug design, with particular attention to the development of new peptides/peptidomimetics that can be used to treat several diseases.

In detail, the different approaches routinely used in the lab, both computational and experimental, are deputed to study the molecular bases of different neurological disorders such as Fragile X Syndrome (FXS), Rett syndrome and Alzheimer disease, as well as cancer onset and pathologies due to dysregulation in protein synthesis.

The main effort that is dedicated on the structural and mechanical characterisation of the protein-protein or protein-nucleic acids interaction, aimed at the collection of information needed to guide the design of new molecules that can be used for novel therapeutic strategies.

In the last yeas, the combination of cutting-aged theoretical and experimental approaches allowed us to establish fruitful collaboration with several national and international institutes.