2021


2020




Genomic Signature of Shifts in Selection in a Subalpine Ant and Its Physiological Adaptations. MOLECULAR BIOLOGY AND EVOLUTION, 2020. Cicconardi, Francesco; Krapf, Patrick; D’Annessa, Ilda; Gamisch, Alexander; Wagner, Herbert C; Nguyen, Andrew D; Economo, Evan P; Mikheyev, Alexander S; Guénard, Benoit; Grabherr, Reingard; Andesner, Philipp; Wolfgang, Arthofer; Di Marino, Daniele; Steiner, Florian M; Schlick-Steiner, Birgit C.  https://pubmed.ncbi.nlm.nih.gov/32181804/

A Nicotinamide Phosphoribosyltransferase-GAPDH Interaction Sustains the Stress-induced NMN/NAD + Salvage Pathway in he Nucleus. JOURNAL OF BIOLOGICAL CHEMISTRY, 2020. Grolla, Ambra A; Miggiano, Riccardo; Di Marino, Daniele; Bianchi, Michele; Gori, Alessandro; Orsomando, Giuseppe; Gaudino, Federica; Galli, Ubaldina; Del Grosso, Erika; Mazzola, Francesca; Angeletti, Carlo; Guarneri, Martina; Torretta, Simone; Calabrò, Marta; Boumya, Sara; Fan, Xiaorui; Colombo, Giorgia; Travelli, Cristina; Rocchio, Francesca; Aronica, Eleonora; Wohlschlegel, James A; Deaglio, Silvia; Rizzi, Menico; Genazzani, Armando A; Garavaglia, Silvia.  https://pubmed.ncbi.nlm.nih.gov/31988240/

Insights Into the Binding Mechanism of GC7 to Deoxyhypusine Synthase in Sulfolobus solfataricus: A Thermophilic Model for the Design of New Hypusination Inhibitors. FRONTIERS IN CHEMISTRY, 2020. D’Agostino,Mattia; Motta, Stefano; Romagnoli, Alice; Orlando, Patrick; Tiano, Luca; La Teana, Anna;  Di Marino Daniele.  https://pubmed.ncbi.nlm.nih.gov/33392152/

Cyclase-associated protein 2 dimerization regulates cofilin in synaptic plasticity and Alzheimer’s disease. BRAIN COMMUNICATIONS, 2020. Pelucchi, Silvia; Vandermeulen, Lina; Pizzamiglio, Lara; Aksan, Bahar; Yan, Jing; Konietzny, Anja; Bonomi, Elisa; Borroni, Barbara; Padovani, Alessandro; Rust, Marco B; Di Marino, Daniele; Mikhaylova, Marina; Mauceri, Daniela; Antonucci, Flavia; Edefonti, Valeria; Gardoni, Fabrizio; Di Luca, Monica; Marcello, Elena.  https://academic.oup.com/braincomms/article/2/2/fcaa086/5863245

2019

Structural insight into the binding mode of FXR and GPBAR1 modulators. HANDBOOK EXP. PHARMACOLOGY, 2019. Di Leva, Francesco Saverio; Di Marino, Daniele; Limongelli, Vittorio.  https://pubmed.ncbi.nlm.nih.gov/31161298/

DDT-Drug Discovery Tool: a fast and intuitive graphics user interface for docking and molecular dynamics analysis. BIOINFORMATICS, 2019. Aureli, Simone;  Di Marino, Daniele; Raniolo, Stefano; Limongelli Vittorio.  https://pubmed.ncbi.nlm.nih.gov/31304963/

Ligand Binding, Unbinding, and Allosteric Effects: Deciphering Small-Molecule Modulation of HSP90. JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2019. D’Annessa, Ilda; Raniolo, Stefano; Limongelli, Vittorio; Di Marino, Daniele; Colombo, Giorgio.  https://pubmed.ncbi.nlm.nih.gov/31538783/

Insights into protein sequencing with an α-Hemolysin nanopore by atomistic simulations. SCIENTIFIC REPORTS, 2019. Di Muccio, Giovanni; Rossini, Aldo Eugenio;  Di Marino, Daniele*; Zollo, Giuseppe; Chinappi, Mauro*.  https://www.ncbi.nlm.nih.gov/pubmed/31015503

Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1.  SCIENTIFIC REPORTS, 2019. Di Leva, Francesco Saverio; Festa, Carmen; Carino, Adriana; De Marino, Simona; Marchianò, Silvia;  Di Marino, Daniele; Finamore, Claudia; Monti, Maria Chiara; Zampella, Angela; Fiorucci, Stefano; Limongelli, Vittorio.  https://www.ncbi.nlm.nih.gov/pubmed/30792450

Handling FMRP and its molecular partners: Structural insights into Fragile X Syndrome. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2019. D’Annessa, Ilda; Cicconardi, Francesco;  Di Marino, Daniele.  https://www.ncbi.nlm.nih.gov/pubmed/30905341*Cover issue

Deletion of the KH1 Domain of Fmr1 Leads to Transcriptional Alterations and Attentional Deficits in Rats. CEREBRAL CORTEX, 2029. Golden, Carla E M; Breen, Michael S; Koro, Lacin; Sonar, Sankalp; Niblo, Kristi; Browne, Andrew; Burlant, Natalie;  Di Marino, Daniele; De Rubeis, Silvia; Baxter, Mark G; Buxbaum, Joseph D; Harony-Nicolas, Hala.  https://www.ncbi.nlm.nih.gov/pubmed/30877790

2018

A Novel Mecp2 Y120D Knock-in Model Displays Similar Behavioral Traits But Distinct Molecular Features Compared to the Mecp2-Null Mouse Implying Precision Medicine for the Treatment of Rett Syndrome.  MOLECULAR NEUROBIOLOGY, 2018. Gandaglia, Anna; Brivio, Elena; Carli, Sara; Palmieri, Michela; Bedogni, Francesco; Stefanelli, Gilda; Bergo, Anna; Leva, Barbara; Cattaneo, Chiara; Pizzamiglio, Lara; Cicerone, Marco; Bianchi, Veronica; Kilstrup-Nielsen, Charlotte; D’Annessa, Ilda;  Di Marino, Daniele; D’Adamo, Patrizia; Antonucci, Flavia; Frasca, Angelisa; Landsberger, Nicoletta.  https://www.ncbi.nlm.nih.gov/pubmed/30402709

Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction: Atomistic characterization of a Rett syndrome causing mutation.  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2018. D’Annessa, Ilda; Gandaglia, Anna; Brivio, Elena; Stefanelli, Gilda; Frasca, Angelisa; Landsberger, Nicoletta;  Di Marino, Daniele.  https://www.ncbi.nlm.nih.gov/pubmed/29428602

2017

Prospective investigation of FOXP1 syndrome. MOLECULAR AUTISM, 2017. Siper, Paige M.; De Rubeis, Silvia; Trelles, Maria Del Pilar; Durkin, Allison;  Di Marino, Daniele; Muratet, François; Frank, Yitzchak; Lozano, Reymundo; Eichler, Evan E.; Kelly, Morgan; Beighley, Jennifer; Gerdts, Jennifer; Wallace, Arianne S.; Mefford, Heather C.; Bernier, Raphael A.; Kolevzon, Alexander; Buxbaum, Joseph D.  https://www.ncbi.nlm.nih.gov/pubmed/29090079

Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase. NEURAL PLASTICITY, 2017. Biggi, Silvia; Buccarello, Lucia; Sclip, Alessandra; Lippiello, Pellegrino; Tonna, Noemi; Rumio, Cristiano;  Di Marino, Daniele; Miniaci, Maria Concetta; Borsello, Tiziana.  https://www.ncbi.nlm.nih.gov/pubmed/28367336

Chemosensory adaptations of the mountain fly Drosophila nigrosparsa (Insecta: Diptera) through genomics’ and structural biology’s lenses.  SCIENTIFIC REPORTS, 2017. Cicconardi, Francesco;  Di Marino, Daniele; Olimpieri, Pier Paolo; Arthofer, Wolfgang; Schlick-Steiner, Birgit C.; Steiner, Florian M.  https://www.ncbi.nlm.nih.gov/pubmed/28256589

2016

Brain phosphorylation of MeCP2 at serine 164 is developmentally regulated and globally alters its chromatin association.  SCIENTIFIC REPORTS, 2016. Stefanelli, Gilda; Gandaglia, Anna; Costa, Mario; Cheema, Manjinder;  Di Marino, Daniele; Barbiero, Isabella; Kilstrup-Nielsen, Charlotte; Ausió, Juan; Landsberger, Nicoletta.  https://www.ncbi.nlm.nih.gov/pubmed/27323888

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes. NATURE GENETICS, 2016. Dooley, James; Tian, Lei; Schonefeldt, Susann; Delghingaro-Augusto, Viviane; Garcia-Perez, Josselyn E.; Pasciuto, Emanuela;  Di Marino, Daniele; Carr, Edward J.; Oskolkov, Nikolay; Lyssenko, Valeriya; Franckaert, Dean; Lagou, Vasiliki; Overbergh, Lut; Vandenbussche, Jonathan; Allemeersch, Joke; Chabot-Roy, Genevieve; Dahlstrom, Jane E.; Laybutt, D. Ross; Petrovsky, Nikolai; Socha, Luis; Gevaert, Kris; Jetten, Anton M.; Lambrechts, Diether; Linterman, Michelle A.; Goodnow, Chris C.; Nolan, Christopher J.; Lesage, Sylvie; Schlenner, Susan M.; Liston, Adrian.  https://www.ncbi.nlm.nih.gov/pubmed/26998692

2015

Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: A novel pharmacological strategy against brain injury.  CELL DEATH & DISEASE, 2015. Vercelli, Alessandr; Biggi, Silvia; Sclip, Alessandra; Repetto, I. E.; Cimini, S.; Falleroni, F.; Tomasi, S.; Monti, R.; Tonna, N.; Morelli, F.; Grande, V.; Stravalaci, M.; Biasini, Emiliano; Marin, O.; Bianco, Fabio;  Di Marino, Daniele; Borsello, Tiziana.  https://www.ncbi.nlm.nih.gov/pubmed/26270349

MD and Docking Studies Reveal That the Functional Switch of CYFIP1 is Mediated by a Butterfly-like Motion. JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2015.  Di Marino, Daniele; Chillemi, Giovanni; De Rubeis, Silvia; Tramontano, Anna; Achsel, Tilmann; Bagni, Claudia.  https://www.ncbi.nlm.nih.gov/pubmed/26575774

All-Atom Molecular Dynamics Simulation of Protein Translocation through an α-Hemolysin Nanopore. THE JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2015.  Di Marino, Daniele; Bonome, Emma Letizia; Tramontano, Anna; Chinappi, Mauro.  https://www.ncbi.nlm.nih.gov/pubmed/26267189

A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors.  PROTEIN SCIENCE, 2015.  Di Marino, Daniele*; D’Annessa, Ilda; Tancredi, Holly; Bagni, Claudia; Gallicchio, Emilio*.  https://www.ncbi.nlm.nih.gov/pubmed/26013047

Characterization of the differences in the cyclopiazonic acid binding mode to mammalian and P. Falciparum Ca2+ pumps: A computational study.  PROTEINS, 2015.  Di Marino, Daniele; D’Annessa, Ilda; Coletta, Andrea; Via, Allegra; Tramontano, Anna.  https://www.ncbi.nlm.nih.gov/pubmed/25581715

2014

SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation. CELL DEATH & DISEASE, 2014. Saraceno, Claudia; Marcello, Elena;  Di Marino, Daniele; Borroni, Barbara; Claeysen, S.; Perroy, J.; Padovani, Alessandro; Tramontano, Anna; Gardoni, Fabrizio; Di Luca, Monica.  https://www.ncbi.nlm.nih.gov/pubmed/25429624

The crystal structure of Giardia duodenalis 14-3-3 in the apo form: When protein post-translational modifications make the difference. PLOS ONE, 2014. Fiorillo, Annarita;  Di Marino, Daniele; Bertuccini, Lucia; Via, Allegra; Pozio, Edoardo; Camerini, Serena; Ilari, Andrea; Lalle, Marco.  https://www.ncbi.nlm.nih.gov/pubmed/24658679

Molecular dynamics simulations show how the FMRP Ile304Asn mutation destabilizes the KH2 domain structure and affects its function JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2014.  Di Marino, Daniele; Achsel, Tilmann; Lacoux, Caroline; Falconi, Mattia; Bagni, Claudia.  https://www.ncbi.nlm.nih.gov/pubmed/23527791

2013

CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic Spine formation. NEURON, 2013. De Rubeis, Silvia; Pasciuto, Emanuela; Li, Kawan; Fernández, Esperanza;  Di Marino, Daniele; Buzzi, Andrea; Ostroff, Linnaeae.; Klann, Eric; Zwartkruis, Fried J. T.; Komiyama, Noboruh.; Grant, Seth G. N.; Poujol, Christel; Choquet, Daniel; Achsel, Tilmann; Posthuma, Danielle; Smit, Augustb.; Bagni, Claudia.  https://www.ncbi.nlm.nih.gov/pubmed/24050404

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease. THE JOURNAL OF CLINICAL INVESTIGATION, 2013. Marcello, Elena; Saraceno, Claudia; Musardo, Stefano; Vara, Hugo; De La Fuente, Alerie Guzman; Pelucchi, Silvia;  Di Marino, Daniele; Borroni, Barbara; Tramontano, Anna; Pérez-Otaño, Isabel; Padovani, Alessandro; Giustetto, Maurizio; Gardoni, Fabrizio; Di Luca, Monica.  https://www.ncbi.nlm.nih.gov/pubmed/23676497

2012

BC1-FMRP interaction is modulated by 2′-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses.  NUCLEIC ACIDS RESEARCH, 2012. Lacoux, Caroline;  Di Marino, Daniele; Boyl, Pietro Pilo; Zalfa, Francesca; Yan, Bing; Ciotti, Maria Teresa; Falconi, Mattia; Urlaub, Henning; Achsel, Tilmann; Mougin, Annie; Caizergues-Ferrer, Michèle; Bagni, Claudia.  https://www.ncbi.nlm.nih.gov/pubmed/22238374

Mapping multiple potential ATP binding sites on the matrix side of the bovine ADP/ATP carrier by the combined use of MD simulation and docking  JOURNAL OF MOLECULAR MODELLING, 2012.  Di Marino, Daniele; Oteri, Francesco; Morozzo Della Rocca, Blasco; D’Annessa, Ilda; Falconi, Mattia.  https://www.ncbi.nlm.nih.gov/pubmed/21989959

Molecular and cellular aspects of mental retardation in the Fragile X syndrome: From gene mutation/s to spine dysmorphogenesis.  ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 2012. De Rubeis, Silvia; Fernández, Esperanza; Buzzi, Andrea;  Di Marino, Daniele; Bagni, Claudia.  https://www.ncbi.nlm.nih.gov/pubmed/22351071

2011

JNK3 as a therapeutic target for neurodegenerative diseases. JOURNAL OF ALZHEIMER’S DISEASE, 2010. Antoniou, Xanthi; Falconi, Mattia;  Di Marino, Daniele; Borsello, Tiziana.  https://www.ncbi.nlm.nih.gov/pubmed/21321401

2010

ADP/ATP mitochondrial carrier MD simulations to shed light on the structural-dynamical events that, after an additional mutation, restore the function in a pathological single mutant.  JOURNAL OF STRUCTURAL BIOLOGY, 2010.  Di Marino, Daniele; Oteri, Francesco; Morozzo della Rocca, Blasco; Chillemi, Giovanni; Falconi, Mattia.  https://www.ncbi.nlm.nih.gov/pubmed/20688168

Docking simulation and competitive experiments validate the interaction between the 2, 5-xylidine inhibitor and rigidoporus lignosus laccase.  JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2010. Cambria, Maria Teresa*;  Di Marino, Daniele*; Falconi, Mattia; Garavaglia, Silvia; Cambria, Antonio.  https://www.ncbi.nlm.nih.gov/pubmed/19916571

2008

The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP. CELL, 2008. Napoli, Ilaria; Mercaldo, Valentina; Boyl, Pietro Pilo; Eleuteri, Boris; Zalfa, Francesca; De Rubeis, Silvia;  Di Marino, Daniele; Mohr, Evita; Massimi, Marzia; Falconi, Mattia; Witke, Walter; Costa-Mattioli, Mauro; Sonenberg, Nahum; Achsel, Tilmann; Bagni, Claudia.  https://www.ncbi.nlm.nih.gov/pubmed/18805096*Second page cover immage

Screening of EDA1 gene in X-linked anhidrotic ectodermal dysplasia using DHPLC: Identification of 14 novel mutations in Italian patients.  GENETIC TESTING, 2008. Conte, Chiara; Gambardella, Stefano; Bulli, Cristina; Rinaldi, Fabrizio;  Di Marino, Daniele; Falconi, Mattia; Bramanti, Placido; Desideri, Alessandro; Novelli, Giuseppe.  https://www.ncbi.nlm.nih.gov/pubmed/18666859

2006

Structural dynamics of the mitochondrial ADP/ATP carrier revealed by molecular dynamics simulation studies. PROTEINS, 2006. Falconi, Mattia; Chillemi, Giovamnni;  Di Marino, Daniele; D’Annessa, Ilda; Morozzo Della Rocca, Blasco; Palmieri, Luigi; Desideri, Alessandro https://www.ncbi.nlm.nih.gov/pubmed/16988954