About the Symposium 

In the last decade the study of the relationship between proteins structure and function has acquired a strong importance to understand the molecular causes of several pathologies. The possibility to analyse at high-resolution molecular structures has become a standard approach and, together with the advances in experimental and theoretical approaches, it allows to obtain unprecedented insight into the dynamics and mechanism of action of proteins and macromolecular complexes.

The Marche Structural Biology Centre (MaSBiC) is a facility for High-Throughput Protein Production (HTPP), involving the Department of Life and Environmental Sciences (DiSVA), the Department of Agricultural, Food and Environmental Sciences (D3A) and the Faculty of Medicine and Surgery of the Polytechnic University of Marche (UNIVPM). The MaSBiC was created in 2015 as part of a very close partnership with the High-Throughput Protein Production laboratory of the New York Structural Biology Centre (NYSBC, www.nysbc.org).

After six years of prolific activity, we considered it appropriate to organise a two-days meeting aimed at sharing knowledge and discussing ideas on the following topic: “ From structure to function: unveiling the role of proteins in health and disease”.

We strongly believe that MaSBiC is the appropriate multi-disciplinary context in which we can organise a symposium focusing on the study of proteins structure and function.

The 1 st MaSBiC – DiSVA Annual Symposium brings together experimental biologists, computational chemists, biochemists, biophysicists and structural and molecular biologists who study different features of proteins such as structure, dynamics, folding, evolution and much more.

Several invited speakers will emphasise a wide range of approaches for tackling important and challenging issues in the study of proteins structure and functions. Furthermore, several slots will be reserved to young researchers to allow them to present their results in short talk.

Two poster sessions will also be organised, helping the participants to share their findings and increase the level of the discussions.


Duration: 2 days

Date: 16-17 September 2021

Location: DiSVA, Aula Azzurra “Mario Giordano”

Due to the COVID-19 Pandemic, the two-days symposium will be held both in presence at Università Politecnica delle Marche (Ancona, Italy) and virtually (i.e., a dedicated Zoom channel will be created).


 



We have a limited number of places available to follow the seminars face-to-face and thus it is very important to register as soon as possible







New York-Marche Structural Biology Center (NY-MaSBiC)




The Lazzaretto of Ancona, also called Mole Vanvitelliana


Confirmed Speakers

1Prof. Silvia De Rubeis  – Cellular and Molecular Neuroscience
Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai, New York, USA.

De Rubesis Lab

2. Prof. Vittorio Limongelli – Computational Biophysics and Medicinal Chemistry
Università della Svizzera italiana (USI), Faculty of Biomedical Sciences – Euler Institute, Lugano, Switzerland.
Limongelli Lab

3. Prof. Eric Ennifar  – Biochemical and Structural Properties of Proteins Targets for Drugs Against Retroviruses
Architecture et Réactivité de l’ARN – CNRS UPR 9002, Université de Strasbourg, Strasbourg, France.
Ennifar Lab 

4.  Prof. Beatrice Vallone  – Structural Biology
Institute of Molecular Biology and Pathology, Department of Biochemical Sciences “Alessandro Fanelli”, University of Rome “La Sapienza”, Rome, Italy.

Vallone Lab

5.  Prof. Martin Weik  – Structural Protein Dynamics
 Universitè Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, Grenoble, France.

Vallone Lab

6.  Prof. Monica Di Luca  – Pharmacology of Neurodegeneration
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.

Di Luca Lab

Program

  Thursday September 16

9.10 – 9.30        Welcome and Introduction

9.30 – 10.10      Prof. Vittorio Limongelli: TBA

10.10 – 10.30    Discussion

10.30 – 10.50    Selected Short Talk

10.50 – 11.00    Discussion

11.00 – 11.30    Coffee Break

11.30 – 11.50    Selected Short Talk

11.50 – 12.00    Discussion

12.00 – 12.20    Selected Short Talk

12.20 – 12.30    Discussion

12.30 – 12.50    Selected Short Talk

12.50 – 13.00    Discussion

13.00 – 14.30     Lunch and Poster Session

14.30 – 15.10     Prof. Martin Weik: TBA 

15.10 – 15.30    Discussion

15.30 – 15.50    Selected Short Talk

15.50 – 16.00     Discussion

16.00 – 16.30     Coffee Break

16.30 – 17.10     Prof. Beatrice Vallone: TBA 

17.10 – 17.30    Discussion

17.30 – 17.50    Selected Short Talk

17.50 – 18.00    Discussion

 

Friday September 17

9.30 – 10.10      Prof. Eric Ennifar: “Biophysical and Structural Approaches to Target the HIV-1 RT genomic RNA”

10.10 – 10.30     Discussion

10.30 – 10.50     Short Talk

10.50 – 11.00     Discussion

11.00 – 11.30     Coffee Break

11.30 – 11.50     Selected Short Talk

11.50 – 12.00     Discussion

12.00 – 12.20     Selected Short Talk

12.20 – 12.30     Discussion

12.30 – 12.50     Selected Short Talk

12.50 – 13.00     Discussion

13.00 – 14.30     Lunch and Poster Session    

14.30 – 15.10     Prof. Monica Di Luca: “Alzheimer Disease and Synaptic Dysfunction: from Identification of Altered Pathways to Drug Discovery”

15.10 – 15.30     Discussion

15.30 – 15.50     Selected Short Talk

15.50 – 16.00     Discussion

16.00 – 16.30     Coffee Break

16.30 – 17.10     Prof. Silvia De Rubeis: “Autism Spectrum Disorder: from Genetic Findings tp Functional Insights”

17.10 – 17.30     Discussion

17.30 – 17.50     Selected Short Talk

17.50 – 18.00     Discussion

18.00 – 18.30     Conclusions and Remarks


Register or Submit an Abstract

Organiser

Prof. Daniele Di Marino
Polytechnic University of Marche, Department of Life and Environmental Science
New York-Marche Structural Biology Center (NY-MaSBiC)Via Brecce Bianche, 60131 Ancona, Italy

E-Mail: d.dimarino@staff.univpm.it 
Interests
: molecular biology; structural biology; computational chemistry; bioinformatics; drug design; protein-protein and protein-nucleic acids interaction


Dr. Cristina Maracci
Polytechnic University of Marche, Department of Life and Environmental Science
New York-Marche Structural Biology Center (NY-MaSBiC)Via Brecce Bianche, 60131 Ancona, Italy

E-Mai
l: maraccicristina@gmail.com
Interests
: molecular biology; structural biology; biochemistry; enzymology; drug design; protein synthesis 


Scientific Committee

Prof. Daniele Di Marino –  Polytechnic University of Marche, Department of Life and Environmental Science (DiSVA), New York-Marche Structural Biology Center (NY-MaSBiC)
Prof. Anna La Teana
 – Polytechnic University of Marche, Department of Life and Environmental Science (DiSVA), New York-Marche Structural Biology Center (NY-MaSBiC)
Prof. Paolo Mariani
 – Polytechnic University of Marche, Department of Life and Environmental Science (DiSVA), New York-Marche Structural Biology Center (NY-MaSBiC)
Prof. Luca Tiano
 – Polytechnic University of Marche, Department of Life and Environmental Science (DiSVA
Dr. Emiliano Trucchi – Polytechnic University of Marche, Department of Life and Environmental Science (DiSVA)
Dr. Luca Maragliano
 – Polytechnic University of Marche, Department of Life and Environmental Science (DiSVA)